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CHICAGO Womens Markus Golden Jersey , Aug. 23 (Xinhua) -- Researchers at the University ofMichigan (UM) recently found that activating the amygdala portionof the brain can intensify one's motivation to consume cocaine farbeyond ordinary drug levels.
"This would suggest that the amygdala plays a key role in drugaddiction," said Shelley Warlow, a UM psychology graduate studentand the study's lead author.
Researchers implanted rats with a catheter that allowed them toearn doses of cocaine by poking their noses into small holes in thewall.
Whenever rats poke their nose into one particular hole to earnintravenous cocaine, a laser light would also painlessly activatethe neurons in the central amygdala at the same time.
Poking their nose into a different hole earned identicalcocaine Womens D.J. Humphries Jersey , but never activated the amygdala.
When being able to freely choose between those two cocainerewards, rats focused only on the port that earned cocaine togetherwith amygdala-activating laser, consumed much more cocaine thanrats without amygdala activation, and avidly nibbled around thelaser-cocaine hole as though seeking more.
Rats with amygdala activation were also willing to work almostthree times harder for the cocaine Womens Robert Nkemdiche Jersey , the study indicated.
Rats appeared to be indifferent to amygdala laser activation.The amygdala activation only intensified motivation when cocainewas present.
By contrast, when the researchers temporarily inactivated theamygdala using a painless drug infusion, rats completely stoppedresponding for cocaine altogether.
"Understanding brain areas and the mechanisms involved in thisintense motivation will be important in developing treatments foraddiction and other compulsive disorders," Warlow said. Enditem
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